Low Concentrated Fractionalized Nanofibers as Suitable Fillers
for Optimization of Structural-Functional Parameters of Dead
Space Gel Implants after Rectal Extirpation

J 2022

Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation

BOCKOVÁ, M.; A. PASHCHENKO; S. STUCHLÍKOVÁ; H. KALÁBOVÁ; R. DIVÍN et. al.

Basic information

Original name

Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation

Authors

BOCKOVÁ, M. (guarantor); A. PASHCHENKO; S. STUCHLÍKOVÁ; H. KALÁBOVÁ; R. DIVÍN; P. NOVOTNÝ; A. KESTLEROVÁ; K. JELEN; P. KUBOVÝ; P. FIRMENT; J. FEDAČKO; T. JAROŠÍKOVÁ; Jiří RULC (203 Czech Republic, belonging to the institution); J. ROSINA; A. NEČAS; Evžen AMLER and J. HOCH

Edition

Gels, 2022, 2310-2861

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10404 Polymer science

Country of publisher

Switzerland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 4.600

Organization unit

AMBIS University

DOI

https://doi.org/10.3390/gels8030158

UT WoS

000775385300001

Keywords in English

dead space; gel rigidification; fractionalized nanofibers; drug delivery system

Links

TL03000207, research and development project.

Changed: 20/4/2023 10:50, Bc. Olga Puldová

Abstract

In the original language

Dead space after rectal resection in colorectal surgery is an area with a high risk of complications. In this study, our goal was to develop a novel 3D implant based on composite hydrogels enriched with fractionalized nanofibers. We employed, as a novel approach in abdominal surgery, the application of agarose gels functionalized with fractionalized nanofibers on pieces dozens of microns large with a well-preserved nano-substructure. This retained excellent cell accommodation and proliferation, while nanofiber structures in separated islets allowed cells a free migration throughout the gel. We found these low-concentrated fractionalized nanofibers to be a good tool for structural and biomechanical optimization of the 3D hydrogel implants. In addition, this nano-structuralized system can serve as a convenient drug delivery system for a controlled release of encapsulated bioactive substances from the nanofiber core. Thus, we present novel 3D nanofiber-based gels for controlled release, with a possibility to modify both their biomechanical properties and drug release intended for 3D lesions healing after a rectal extirpation, hysterectomy, or pelvic exenteration.

Cite

BOCKOVÁ, M.; A. PASHCHENKO; S. STUCHLÍKOVÁ; H. KALÁBOVÁ; R. DIVÍN; P. NOVOTNÝ; A. KESTLEROVÁ; K. JELEN; P. KUBOVÝ; P. FIRMENT; J. FEDAČKO; T. JAROŠÍKOVÁ; Jiří RULC; J. ROSINA; A. NEČAS; Evžen AMLER and J. HOCH. Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation. Gels. 2022, vol. 8, No 3, p. 1-16. ISSN 2310-2861. Available from: https://doi.org/10.3390/gels8030158.

@article{486663,
   author = {Bocková, M. and Pashchenko, A. and Stuchlíková, S. and Kalábová, H. and Divín, R. and Novotný, P. and Kestlerová, A. and Jelen, K. and Kubový, P. and Firment, P. and Fedačko, J. and Jarošíková, T. and Rulc, Jiří and Rosina, J. and Nečas, A. and Amler, Evžen and Hoch, J.},
   article_number = {3},
   doi = {https://doi.org/10.3390/gels8030158},
   keywords = {dead space; gel rigidification; fractionalized nanofibers; drug delivery system},
   language = {eng},
   issn = {2310-2861},
   journal = {Gels},
   title = {Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation},
   url = {https://www.mdpi.com/2310-2861/8/3/158},
   volume = {8},
   year = {2022}
}

TY  - JOUR
ID  - 486663
AU  - Bocková, M. - Pashchenko, A. - Stuchlíková, S. - Kalábová, H. - Divín, R. - Novotný, P. - Kestlerová, A. - Jelen, K. - Kubový, P. - Firment, P. - Fedačko, J. - Jarošíková, T. - Rulc, Jiří - Rosina, J. - Nečas, A. - Amler, Evžen - Hoch, J.
PY  - 2022
TI  - Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation
JF  - Gels
VL  - 8
IS  - 3
SP  - 1-16
EP  - 1-16
SN  - 23102861
KW  - dead space
KW  - gel rigidification
KW  - fractionalized nanofibers
KW  - drug delivery system
UR  - https://www.mdpi.com/2310-2861/8/3/158
N2  - Dead space after rectal resection in colorectal surgery is an area with a high risk of complications. In this study, our goal was to develop a novel 3D implant based on composite hydrogels enriched with fractionalized nanofibers. We employed, as a novel approach in abdominal surgery, the application of agarose gels functionalized with fractionalized nanofibers on pieces dozens of microns large with a well-preserved nano-substructure. This retained excellent cell accommodation and proliferation, while nanofiber structures in separated islets allowed cells a free migration throughout the gel. We found these low-concentrated fractionalized nanofibers to be a good tool for structural and biomechanical optimization of the 3D hydrogel implants. In addition, this nano-structuralized system can serve as a convenient drug delivery system for a controlled release of encapsulated bioactive substances from the nanofiber core. Thus, we present novel 3D nanofiber-based gels for controlled release, with a possibility to modify both their biomechanical properties and drug release intended for 3D lesions healing after a rectal extirpation, hysterectomy, or pelvic exenteration.
ER  -

BOCKOVÁ, M.; A. PASHCHENKO; S. STUCHLÍKOVÁ; H. KALÁBOVÁ; R. DIVÍN; P. NOVOTNÝ; A. KESTLEROVÁ; K. JELEN; P. KUBOVÝ; P. FIRMENT; J. FEDAČKO; T. JAROŠÍKOVÁ; Jiří RULC; J. ROSINA; A. NEČAS; Evžen AMLER and J. HOCH. Low Concentrated Fractionalized Nanofibers as Suitable Fillers for Optimization of Structural-Functional Parameters of Dead Space Gel Implants after Rectal Extirpation. \textit{Gels}. 2022, vol.~8, No~3, p.~1-16. ISSN~2310-2861. Available from: https://doi.org/10.3390/gels8030158.

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