Myrtle-Functionalized Nanofibers Modulate Vaginal Cell
Population Behavior While Counteracting Microbial Proliferation

J 2022

Myrtle-Functionalized Nanofibers Modulate Vaginal Cell Population Behavior While Counteracting Microbial Proliferation

BELLU, E.; N. DIAZ; M. KRALOVIČ; R. DIVIN; G. SARAIS et. al.

Basic information

Original name

Myrtle-Functionalized Nanofibers Modulate Vaginal Cell Population Behavior While Counteracting Microbial Proliferation

Authors

BELLU, E.; N. DIAZ; M. KRALOVIČ; R. DIVIN; G. SARAIS; A. FADDA; R. SATTA; M. A. MONTESU; S. MEDICI; A. BRUNETTI; A. BARCESSAT; T. JAROŠÍKOVÁ; Jiří RULC (203 Czech Republic, belonging to the institution); Evžen AMLER (guarantor); V. MARGARITA; P. RAPPELLI and M. MAIOLI

Edition

Plants, 2022, 2223-7747

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10600 1.6 Biological sciences

Country of publisher

Switzerland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 4.500

Organization unit

AMBIS University

DOI

https://doi.org/10.3390/plants11121577

UT WoS

000816625100001

Keywords in English

myrtle; plant extracts; bioactive compounds; health promoting; nanomaterials; antimicrobial activity; cell behavior; vaginal infections

Links

TL03000207, research and development project.

Changed: 20/4/2023 10:36, Bc. Olga Puldová

Abstract

In the original language

Vaginal infections affect millions of women annually worldwide. Therapeutic options are limited, moreover drug-resistance increases the need to find novel antimicrobials for health promotion. Recently phytochemicals were re-discovered for medical treatment. Myrtle (Myrtus communis L.) plant extracts showed in vitro antioxidant, antiseptic and anti-inflammatory properties thanks to their bioactive compounds. The aim of the present study was to create novel nanodevices to deliver three natural extracts from leaves, seeds and fruit of myrtle, in vaginal milieu. We explored their effect on human cells (HeLa, Human Foreskin Fibroblast-1 line, and stem cells isolated from skin), resident microflora (Lactobacillus acidophilus) and on several vaginal pathogens (Trichomonas vaginalis, Escherichia coli, Staphylococcus aureus, Candida albicans, Candida kefyr, Candida glabrata, Candida parapsilosis, Candida krusei). Polycaprolactone-Gelatin nanofibers encapsulated with leaves extract and soaked with seed extracts exhibited a different capability in regard to counteracting microbial proliferation. Moreover, these nanodevices do not affect human cells and resident microflora viability. Results reveal that some of the tested nanofibers are interesting candidates for future vaginal infection treatments.

Cite

BELLU, E.; N. DIAZ; M. KRALOVIČ; R. DIVIN; G. SARAIS; A. FADDA; R. SATTA; M. A. MONTESU; S. MEDICI; A. BRUNETTI; A. BARCESSAT; T. JAROŠÍKOVÁ; Jiří RULC; Evžen AMLER; V. MARGARITA; P. RAPPELLI and M. MAIOLI. Myrtle-Functionalized Nanofibers Modulate Vaginal Cell Population Behavior While Counteracting Microbial Proliferation. Plants. 2022, vol. 11, No 12, p. 1-19. ISSN 2223-7747. Available from: https://doi.org/10.3390/plants11121577.

@article{486662,
   author = {Bellu, E. and Diaz, N. and Kralovič, M. and Divin, R. and Sarais, G. and Fadda, A. and Satta, R. and Montesu, M. A. and Medici, S. and Brunetti, A. and Barcessat, A. and Jarošíková, T. and Rulc, Jiří and Amler, Evžen and Margarita, V. and Rappelli, P. and Maioli, M.},
   article_number = {12},
   doi = {https://doi.org/10.3390/plants11121577},
   keywords = {myrtle; plant extracts; bioactive compounds; health promoting; nanomaterials; antimicrobial activity; cell behavior; vaginal infections},
   language = {eng},
   issn = {2223-7747},
   journal = {Plants},
   title = {Myrtle-Functionalized Nanofibers Modulate Vaginal Cell Population Behavior While Counteracting Microbial Proliferation},
   url = {https://www.mdpi.com/2223-7747/11/12/1577},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 486662
AU  - Bellu, E. - Diaz, N. - Kralovič, M. - Divin, R. - Sarais, G. - Fadda, A. - Satta, R. - Montesu, M. A. - Medici, S. - Brunetti, A. - Barcessat, A. - Jarošíková, T. - Rulc, Jiří - Amler, Evžen - Margarita, V. - Rappelli, P. - Maioli, M.
PY  - 2022
TI  - Myrtle-Functionalized Nanofibers Modulate Vaginal Cell Population Behavior While Counteracting Microbial Proliferation
JF  - Plants
VL  - 11
IS  - 12
SP  - 1-19
EP  - 1-19
SN  - 22237747
KW  - myrtle
KW  - plant extracts
KW  - bioactive compounds
KW  - health promoting
KW  - nanomaterials
KW  - antimicrobial activity
KW  - cell behavior
KW  - vaginal infections
UR  - https://www.mdpi.com/2223-7747/11/12/1577
N2  - Vaginal infections affect millions of women annually worldwide. Therapeutic options are limited, moreover drug-resistance increases the need to find novel antimicrobials for health promotion. Recently phytochemicals were re-discovered for medical treatment. Myrtle (Myrtus communis L.) plant extracts showed in vitro antioxidant, antiseptic and anti-inflammatory properties thanks to their bioactive compounds. The aim of the present study was to create novel nanodevices to deliver three natural extracts from leaves, seeds and fruit of myrtle, in vaginal milieu. We explored their effect on human cells (HeLa, Human Foreskin Fibroblast-1 line, and stem cells isolated from skin), resident microflora (Lactobacillus acidophilus) and on several vaginal pathogens (Trichomonas vaginalis, Escherichia coli, Staphylococcus aureus, Candida albicans, Candida kefyr, Candida glabrata, Candida parapsilosis, Candida krusei). Polycaprolactone-Gelatin nanofibers encapsulated with leaves extract and soaked with seed extracts exhibited a different capability in regard to counteracting microbial proliferation. Moreover, these nanodevices do not affect human cells and resident microflora viability. Results reveal that some of the tested nanofibers are interesting candidates for future vaginal infection treatments.
ER  -

BELLU, E.; N. DIAZ; M. KRALOVIČ; R. DIVIN; G. SARAIS; A. FADDA; R. SATTA; M. A. MONTESU; S. MEDICI; A. BRUNETTI; A. BARCESSAT; T. JAROŠÍKOVÁ; Jiří RULC; Evžen AMLER; V. MARGARITA; P. RAPPELLI and M. MAIOLI. Myrtle-Functionalized Nanofibers Modulate Vaginal Cell Population Behavior While Counteracting Microbial Proliferation. \textit{Plants}. 2022, vol.~11, No~12, p.~1-19. ISSN~2223-7747. Available from: https://doi.org/10.3390/plants11121577.

Přehled o publikaci