You can specify autoreplay for emails that will be delivered in your absence:
The Information System My mail Settings
Check the box next to "Enable out-of-office auto-reply" and fill in the required fields subject, message and start of absence.
In the case of additional incoming emails from the same sender, the next reply will not be sent until four days later.
Also, an auto-reply will not be sent if an incoming email has been classified as SPAM, system message, or archived email.
Automatic replies cannot be used if you have set up e-mail forwarding outside IS AMBIS.